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    3D Printed Organs and Tissues

    3D Organs
    3D Bioprinting Tissue
    3D Printing Kidney
    Dan Kraft: 3D Organs
    MIT: 3D Organs 

    There has been much talk of 3d Printed Organs and Tissues, lately.  It shows lots of promise, and Organovo of San Diego, a big player in the 3d Bioprinting field, predicts that artificial liver tissue will be printed by 2019!  3d Printing tissues and organs is a complex procedure, and …involves additional complexities, such as the choice of materials, cell types, growth and differentiation factors, and technical challenges related to the sensitivities of living cells and the construction of tissues. Addressing these complexities requires the integration of technologies from the fields of engineering, biomaterials science, cell biology, physics and medicine.

    3D bioprinting has already been used for the generation and transplantation of several tissues, including multilayered skin, bone, vascular grafts, tracheal splints, heart tissue and cartilaginous structures.  3d Printing of tissue not only has application for transplant into humans, but also provides a method of testing new drugs on 3d Printed tissue, without subjecting animals to drug trials.

    See this article from Wake Forest University in North Carolina, very active in stem cell research and 3d Printing, where they have  …successfully implanted living, functional 3D printed Human tissue into Animals….

    The news has been full of stories about new advancements in 3D printed tissue. Companies such as and research institutions such as theare leading the charge in the development of 3D printed, functional human tissue, particularly liver tissue. So far, printed tissue is being used mostly for pharmaceutical drug testing, but everyone in the 3D printing biosphere professes the ultimate goal of eventually producing whole, fully functional human organs that can be transplanted into patients. Most experts agree that it will happen; it’s just a matter of when.

    It’s also a matter of who. The race to be the first to 3D print a transplantable human organ is an intense one, and may have just pulled into the lead. Regenerative medicine researchers at the North Carolina hospital have announced that they have printed ear, bone and muscle structures and successfully implanted them into animals. The structures, after being implanted, matured into functional tissue and sprouted new systems of blood vessels, and their strength and size mean that they could feasibly be implanted into humans in the future.

    Dr. Anthony Atala

    “We make ears the size of baby ears. We make jawbones the size of humanjawbones,” said Anthony Atala, M.D., director of the (WFIRM). “We are printing all kinds of things.”

    Dr. Atala has long been a major player in the field of regenerative medicine. In 2006 his lab made history by growing and implanting a bladder into a human patient – the first time such a feat had ever been accomplished. He and his team have been developing the Integrated Tissue and Organ Printing System (ITOP) over the past decade. The system involves a custom-designed 3D printer that utilzes a water-based ink optimized to promote the health and growth of encapsulated cells, which are printed in alternating layers with biodegradable plastic micro-channels that act as passages for nutrients. Unlike other bioprinting methods, ITOP prints the cells and the scaffolds simultaneously, according to Dr. Atala.

    “This novel tissue and organ printer is an important advance in our quest to make replacement tissue for patients,” he said. “It can fabricate stable, human-scale tissue of any shape. With further development, this technology could potentially be used to print living tissue and organ structures for surgical implantation.”

    Wake Forest’s research has been largely funded by the, a military organization for severely injured soldiers. The development of transplantable, 3D printed tissue could obviously benefit both military personnel and civilians, though – according to the , over 121,000 Americans are currently on the waiting list for an organ transplant. The ITOP system could eliminate waiting lists altogether with “made to order” organs custom-designed for individual patients based on MRI and CT scans.

    We’re still years away from that, but it’s been five months since 3D printed bone fragments were implanted into rats, and the tissue is still thriving inside the rodents’ bodies. One of the biggest challenges in bioprinting so far has been getting printed tissue to survive long enough to form blood vessels and nerves and otherwise fully integrate with the body in which it is implanted, so this study is incredibly promising. You can access the study. Discuss these new advances in the over at 3DPB.com.

     

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