• Harvard University researchers have made the first entirely 3D-printed organ-on-a-chip with integrated sensing.  Built by a fully automated, digital manufacturing procedure, the 3D-printed heart-on-a-chip can be quickly fabricated and customized, allowing researchers to easily collect reliable data for short-term and long-term studies.

    This new approach to manufacturing may one day allow researchers to rapidly design organs-on-chips, also known as microphysiological systems, that match the properties of a specific disease or even an individual patient’s cells.

    The research is published in .

    “This new programmable approach to building organs-on-chips not only allows us to easily change and customize the design of the system but also drastically simplifies data acquisition,” said Johan Ulrik Lind, first author of the paper and postdoctoral fellow at the (SEAS).  Lind is also a researcher at the .

    “Our microfabrication approach opens new avenues for in vitro tissue engineering, toxicology and drug screening research,” said , Tarr Family Professor of Bioengineering and Applied Physics at SEAS, who coauthored the study. Parker is also a Core Faculty Member of the Wyss Institute.

    Organs-on-chips mimic the structure and function of native tissue and have emerged as a promising alternative to traditional animal testing. Harvard researchers have developed microphysiological systems that mimic the microarchitecture and functions of lungs, hearts, tongues and intestines.

    However, the fabrication and data collection process for organs-on-chips is expensive and laborious. Currently, these devices are built in clean rooms using a complex, multi-step lithographic process and collecting data requires microscopy or high-speed cameras.

    “Our approach was to address these two challenges simultaneously via digital manufacturing,” said Travis Busbee, coauthor of the paper and graduate student in the Lewis Lab.  “By developing new printable inks for multi-material 3D printing, we were able to automate the fabrication process while increasing the complexity of the devices.”

    The researchers developed six different inks that integrated soft strain sensors within the micro-architecture of the tissue. In a single, continuous procedure, the team 3D printed those materials into a cardiac microphysiological device — a heart on a chip — with integrated sensors.

    “We are pushing the boundaries of three-dimensional printing by developing and integrating multiple functional materials within printed devices,” said , Hansjorg Wyss Professor of Biologically Inspired Engineering, and coauthor of the study. “This study is a powerful demonstration of how our platform can be used to create fully functional, instrumented chips for drug screening and disease modeling.”

    Lewis is also a Core Faculty Member of the Wyss Institute.

    The chip contains multiple wells, each with separate tissues and integrated sensors, allowing researchers to study many engineered cardiac tissues at once. To demonstrate the efficacy of the device, the team performed drug studies and longer-term studies of gradual changes in the contractile stress of engineered cardiac tissues, which can occur over the course of several weeks.

    “Researchers are often left working in the dark when it comes to gradual changes that occur during cardiac tissue development and maturation because there has been a lack of easy, non-invasive ways to measure the tissue functional performance,” said Lind. “These integrated sensors allow researchers to continuously collect data while tissues mature and improve their contractility. Similarly, they will enable studies of gradual effects of chronic exposure to toxins.”

    “Translating microphysiological devices into truly valuable platforms for studying human health and disease requires that we address both data acquisition and manufacturing of our devices,” said Parker. “This work offers new potential solutions to both of these central challenges.”

    This work was supported by the National Science Foundation, the National Center for Advancing Translational Sciences of the National Institutes of Health, the US Army Research Laboratory and the US Army Research, and the Harvard University Materials Research Science and Engineering Center (MRSEC).

     
     

    No comments

    Be the first one to leave a comment.

    Post a Comment


     

     

    Latest Posts

    Latest Video

     
     

    LATEST POSTS

    Protected: Top Vape Pens To Buy In 2018 For Use With Weed

    There is no excerpt because this is a protected post.

    What To Do When You Become a Victim of Medical Malpractice

    Currently, medical malpractice ranging from misdiagnosis to medication errors and wrong-site surgery is rampant. Medical malpractice goes against the ethics and ethos of the medical…

    Veda Soothe Review: Can These 5 Herbs Help Stiff and Painful Joints?

    Joint pain is one of the most common health and wellness issues that especially face the middle-aged as well as the old-aged in the society….

    3 Tips for Coping After a Serious Accident

    Nobody wishes to be a part of a serious accident, but unfortunately, sometimes it happens. Whether it happens to be the fault of someone else…

    Sales Management Software Advantages To Remember

    When using sales management software you do gain access to many organizational benefits that the enterprise surely wants to take advantage of, helping achieve profit…

    Knowing the Process: Which Steps Does a Medical Malpractice Trial Involve?

      When you get involved in a medical malpractice, you need to file a suit right away to demand lawful compensation. Beware; these suits can…

    Less the Hassle: Buy Your Hearing Aids Online

    Hearing aids are potent devices that help people with hearing loss. Physically recover the ability to listen with great flexibility. This flexibility involves adjusting the…

    What Are the 4 Benefits of a Good Body Posture?

    Good body posture is as important as our health, appearance, good looks and confidence. When in excellent body posture, you can make that relaxed first…

    www.medicaments-24.com

    yarema.ua

    www.steroid.in.ua/products/nandrolon-fenilpropionat